Document 0586
 DOCN  M9480586
 TI    Study of B and T cell phenotypes in blood from patients with common
       variable immunodeficiency (CVID).
 DT    9410
 AU    Farrant J; Spickett G; Matamoros N; Copas D; Hernandez M; North M;
       Chapel H; Webster AD; Immunodeficiency Diseases Research Group, Clinical
       Research; Centre, Harrow, UK.
 SO    Immunodeficiency. 1994;5(2):159-69. Unique Identifier : AIDSLINE
       MED/94305532
 AB    B and T cell phenotypes in peripheral blood from 71 CVID patients have
       been measured in a study using directly conjugated monoclonal antibodies
       and two colour flow cytometry. Data was compared between different
       patient groups (based on whether their B cells could secrete IgM or IgG
       in vitro) and normal donors. There was a clear correlation between
       abnormalities of both B and T cells and the different patient groups.
       There were reduced absolute numbers of circulating CD4+ T cells,
       particularly those of the CD4+.CD45RA+ subset, and of CD19+ B cells in
       those patients whose B cells failed to secrete IgM or IgG in vitro. This
       demonstrates an association between B cell lymphopenia, failure of B
       cell immunoglobulin production in vitro and T cell subset lymphopenia in
       CVID. It supports the view that this group of CVID patients has a
       disease involving T cell regulation of B cells of varying severity.
 DE    Antibodies, Monoclonal  Antigens, CD3/IMMUNOLOGY
       B-Lymphocytes/*IMMUNOLOGY  Common Variable Immunodeficiency/*IMMUNOLOGY
       CD4-CD8 Ratio  Flow Cytometry  Human  Immunophenotyping  Leukocyte Count
       Lymphopenia/IMMUNOLOGY  Support, Non-U.S. Gov't
       T-Lymphocytes/*IMMUNOLOGY  T-Lymphocytes, Suppressor-Effector/IMMUNOLOGY
       T4 Lymphocytes/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).